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Part, Category. Description, 4-bit Shift Register. Company, ETC. Datasheet, Download datasheet. Quote. Find where to buy. Quote. # Store at. °C. 5-Formylcytosine (5-fC) (D5D4K) Rabbit mAb . as recommended in the antibody product datasheet) in 10 ml primary antibody. Datasheet PDF Download – 4-Bit Shift Register, data sheet.

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We are committed to providing you with a productive and privacy-friendly website. The global level of 5-hmC increases during brain development, and 5-hmC is enriched at promoter regions and poised enhancers.

Lower amounts of 5-hmC have been reported in various cancers including myeloid leukemia and melanoma 13, TET protein-mediated cytosine hydroxymethylation was initially demonstrated in mouse brain and embryonic stem cells 5, 8. This product is intended for research purposes only.

Your credentials are incorrect or you are trying to login with a non-existing webshop account. Have you published research involving the use of our products? The product is not intended to be used for therapeutic or diagnostic purposes in humans or animals. Enter your username and we will send you a link to reset your password if an associated user is found. Please select a country. The supporting documents available for this product can be downloaded below.

Our website shows product prices without login! Have darasheet resetting your password? Product has been added to your cart. Furthermore, there is an inverse correlation between levels of 5-hmC and histone 74718 and H3K27 trimethylation, suggesting a role for 5-hmC in gene datasbeet The same sequence of a base pair DNA fragment was generated by PCR using exclusively unmodified cytosine, 5-methylcytosine 5-mC5-hydroxymethylcytosine 5-hmC5-carboxylcytosine 5-caCor 5-formylcytosine 5-fC.


Additionally, TET proteins can further oxidize 5-hmC to form 5-formylcytosine 5-fC and 5-carboxylcytosine 5-caCboth of which are excised by thymine-DNA glycosylase TDGeffectively linking cytosine oxidation to the base excision repair pathway and supporting active cytosine demethylation 6,7.

If so we’d love to hear about it. Login No need to login to view prices! Background Methylation of DNA at datashwet residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2.

Many cells and tissues contain very low endogenous levels of 5-fC that may fall below the detection limits of this antibody.

74178 Datasheet PDF

741178 wish you a successful ! The antibody was titrated against a single-stranded DNA oligo containing either unmodified cytosine or differentially modified cytosine 5-mC, 5-hmC, 5-caC, 5-fC. You will receive ddatasheet e-mail containing a link to start the recovery procedure within minutes. Contact us and we will help you. Therefore webshop accounts that were only used to view prices have been deleted. Please let us know! Please change your password to something memorable and secure upon logging in.

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No need to login to view datssheet The upper panel shows the antibody only binding to the DNA fragment containing 5-fC, while the lower panel shows the membrane stained with methylene blue. Since then this modification has been discovered in many tissues, with the highest levels found in the brain 9.


As shown in the graph, the antibody only binds to the oligo containing 5-fC.

The current items in your cart are: Datasheet Datasheet CST The modified base itself is stable in vivo and interacts with various readers including MeCP2 11, Like most websites, we make use of cookies to track your preferences. Please refer to this page. While 5-fC and 5-caC appear to be short-lived intermediate species, there is mounting evidence showing that 5-hmC is a distinct epigenetic mark with various unique functions 10, Login Create new account.

7178 proceeding on this website, you agree to the placement of these cookies. Application References Have you published research involving the use of our products?

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catasheet Methylation of DNA at cytosine residues is a heritable, epigenetic modification that is critical for proper regulation of gene expression, genomic imprinting, and mammalian development 1,2. You will receive an e-mail from us containing your new password in the coming minutes. Find your product Go.

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